List of publications on a keyword: «mechanism of action»


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Publication date: 16.10.2020
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Andrey V. Antsyborov , graduate student
Mental Health Clinic «Psyche» , Ростовская обл
Irina V. Dubatova , candidate of medical sciences , associate professor
FSFEI of HE “Rostov State Medical University” of Russian Ministry of Health , Ростовская обл
Anna V. Kalinchuk , candidate of biological sciences , professor
Harvard University , USA

«Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry»

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In recent decades, sleep deprivation has evolved from a single experimental data set to the status of an effective and affordable therapeutic intervention used in daily clinical practice. The mechanism of action of this method is aimed at the same neurotransmitter systems and brain regions as antidepressants. As in the case of pharmacotherapy for sleep deprivation, it should be used under close supervision of a physician. Clinical effects with sleep deprivation are achieved much faster than with psychopharmacotherapy, but they are not long-term in nature. It is possible to improve the results using a combination of pharmacotherapy and sleep deprivation. The use of sleep deprivation in clinical conditions is aimed primarily at preventing depression and its recurrence, as well as in cases resistant to pharmacotherapy. In modern conditions, the method of sleep deprivation is a significant alternative to traditional approaches to therapy of depression.

Publication date: 26.02.2021
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Vladimir G. Zaika , doctor of medical sciences , professor, head of chair
Irina V. Dubatova , candidate of medical sciences , associate professor
FSFEI of HE “Rostov State Medical University” of Russian Ministry of Health , Ростовская обл
Andrey V. Antsyborov , graduate student
Mental Health Clinic «Psyche» , Ростовская обл

«Evidence-Based Pharmacotherapy of ADHD»

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Attention deficit hyperactivity disorder (ADHD) is a widespread, severe neurobiological disorder that occurs in childhood and adolescence and has a negative impact on social functioning in adulthood. Currently, there are several strategies for the treatment of ADHD including pharmacotherapy and psychotherapeutic interventions. Due to the expansion of the range of available drugs, for practical doctors to choose the tactics of therapy and to set priorities in the treatment process becomes more challenging. The aim of this review is to systematize the evidence-based literature on the treatment of ADHD, based on the principles of evidence-based medicine. The review considers the main mechanisms of action of the drugs used, the role of non-drug methods of treatment, as well as drugs that are not widely used. The most relevant treatment approaches, which have been proven to be effective and safe, are discussed.